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Beyond Biomarkers: Applications for Personalized Treatments

Only two medications are FDA-approved for the treatment of Bipolar Disorder. Whether antidepressants are helpful for depressive episodes in bipolar disorder is still a controversial topic. A meta-analysis across16 studies found no significant positive or negative effect from treating bipolar patients with antidepressants. However, antidepressants are affective for some patients, meaning that physicians should not and will not entirely dismiss them from a possible treatment route. The Mayo Clinic in Rochester, MN, is conducting a clinical trial examining the use of anti-glutamate meds in treating depressive episodes in bipolar disorder instead of antidepressants.


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