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Depression Center Colloquium Series

Environment and Epigenetics


Feb 13, 2015


12:00 - 13:00


Auditorium, Rachel Upjohn Building
4250 Plymouth Road
Ann Arbor, Michigan 


Srijan Sen, MD, PhD
Assistant Professor, Department of Psychhiatry

Dr. Sen earned his bachelor’s degree at Cornell University, and then studied at Oxford University before completing the M.D. / Ph.D. program in 2005 at the University of Michigan Medical School. He performed his residency in psychiatry at Yale University and joined the University of Michigan Medical School Faculty in 2009. While there has been growing interest in gene-stress interactions in depression over the past decade, progress has been limited because the onset of stressful situations is difficult to predict beforehand, and because the type of stress encountered varies widely between individuals. Dr. Sen’s primary project seeks to overcome these barriers by studying medical interns as a model of individuals under stress. Medical internship, the first year of professional physician training, presents a unique situation where the onset of a uniform, chronic stressor can be prospectively predicted. Dr. Sen’s laboratory is using cutting edge genomic techniques in the internship sample to identify common and rare genetic variation involved in moderating the relationship between stress and depression. In addition, he is using the medical internship model to identify non-genetic peripheral biomarkers that predict the development of depression under stress. His aim is to identify subtypes of depression that may be amenable to different treatments and ultimately to identify novel therapeutic targets for antidepressants that will improve the lives of people suffering from depression. Dr. Sen has received numerous grants and awards, including the American College of Psychiatry’s Laughlin Fellowship. His work has been featured in the New York Times, Time Magazine, ABC News and CBS Radio.

Faculty Disclosure:

Dana Dolinoy, PhD
John G. Searle Assistant Professor, Environmental Health Sciences, School of Public Health, University of Michigan

Dr. Dana Dolinoy is Associate Professor of Environmental Health Sciences at the University of Michigan School of Public Health (UM SPH) and leads the Environmental Epigenetics and Nutrition Laboratory at UM SPH, which investigates how nutritional and environmental factors interact with epigenetic gene regulation to shape health and disease. Dr. Dolinoy holds a BA in environmental sciences and policy and Spanish from Duke University, an MSc in environmental sciences and engineering from the Harvard School of Public Health, and a PhD in Genetics and Genomics and Integrated Toxicology from Duke University. She serves on the Editorial Board for the Journal of Nutritional Biochemistry as well as Epigenetics, Environmental and Molecular Mutagenesis, and Toxicological Sciences, and is an active member of the Society of Toxicology (SOT), the Environmental Mutagen and Genomics Society (EMGS), and the American Society for Nutrition (ASN), and will serve as Chair of the 2015 Gordon Research Conference (GRC) in Molecular & Cellular Mechanisms of Toxicity. In 2011, Dr. Dolinoy received the Norman Kretchmer Memorial Award from ASN and the Classic Paper of the Year Award from Environmental Health Perspectives for Dolinoy et al. "Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome." In 2012, she was the recipient of the Association of Schools of Public Health (ASPH)/Pfizer Research Award for the article, "An Expression Microarray Approach for the Identification of Metastable Epialleles in the Mouse Genome." This work was cited as a model approach that may allow for directly assessing the role of early nutritional and environmental exposures in human adult disease.

Faculty Disclosure:

CME Eligible: Yes

Live Webcast:
If you are unable to attend in-person, please check this webpage on the day of the event for a link to a live webcast of the presentation. To view the webcast, please make sure you have the following: a Broadband connection, Adobe Flash Player version 8 or higher, U-M Weblogin* (uniqname and kerberos password)
*if you do not have a U-M Weblogin, please create a "Friend Account."


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