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Treatment for Anxiety Disorders

Synopsis of treatment for anxiety disorders:


Many variables influence the selection of medication for individual patients. The following is general information regarding beginning treatment.

Most common - sertraline (Zoloft), citalopram (Celexa), and escitalopram (Lexparo).  These allow a low starting dose (12.5mg of Zoloft, 5mg of Celexa) and slow titration (anxiety patients are very vulnerable to initial activation and worsening of symptoms). Effective ranges: 50-200 mg of Zoloft, 20-40 mg of Celexa, and 10-20 mg of Lexapro. We routinely utilize much higher doses than those previously listed to treat OCD.

Sertraline may have fewer interactions with P450 enzymes. Citalopram (Celexa) and escitalopram (Lexapro) also have low interaction with P450 enzymes. We have experience using fluoxetine (Prozac) in very high doses (up to 120 mg/day), so it is often preferred in treatment-resistant OCD. That said, its long duration of action and tendency to be activating undermine our ability to use it as first line treatment for all anxiety disorders. Given its potent serotonergic properties, high-dose Lexapro (40 mg/day or even higher) is also a reasonable choice for OCD, though it can be activating, as well.  Paroxetine is commonly used in primary care contexts, and is less activating and somewhat sedating in some patients.  This can be advantageous in selected cases, but it also seems to more often produce weight gain and unusual cognitive effects, as well as higher rates of discomfort during discontinuation efforts.

We rarely use benzodiazepines as first line drugs for these disorders and generally discourage as needed/rescue use. Benzodiazepines remain widely used drugs for panic and other anxiety disorders in both primary care and mental health settings. While they have clear value in some circumstances, we avoid them as first line treatments because they so powerfully reinforce the anxious patient's wish for a simple and quick way to avoid the distressing experience of his or her anxiety. Overcoming this desire to flee distressing circumstances or feelings is the bedrock of CBT and is absolutely critical to successful long-term outcomes. Benzodiazepines often make these efforts more difficult.

Cognitive-Behavioral Therapy (CBT):

Highly specific treatments for each of these anxiety disorders have been developed and have proven efficacy in well-controlled trials. New data and APA guidelines now support CBT as a first line treatment for Panic Disorder. CBT clearly enhances long-term outcomes.

Basic Principles of Cognitive-Behavioral Therapy (CBT) for Anxiety Disorders: Fundamental Law of Anxiety and Exposure Therapy

Anything that triggers anxiety tends to be avoided. If frightening objects or situations are avoided, they will become more frightening over time. If the avoidance is overcome, and frightening objects or situations are repeatedly confronted without leading to the anticipated dangerous outcome, they become less frightening. We call this desensitization, and it can only occur through exposure. Fear of any anxiety arousing object or situation can be desensitized by a properly managed and structured exposure program. When done properly it always works. So, whenever the clinical picture includes anxiety cued by specific objects or situations, exposure principles are important to the treatment.

Panic Disorder

Goal 1: Reduce fear of panic attacks themselves.

Primary technique: Cognitive restructuring

Approach: A central issue for most patients with panic disorder is an intense fear of the sensations they experience during a panic attack. These fears often include catastrophic misperceptions that something terrible may happen during a panic attack such as dying, having a heart attack, experiencing a stroke, fainting, smothering, going crazy or losing control. These "catastrophic misinterpretations" contribute to a "fear of fear" cycle that begins to trigger and intensify attacks in response to benign physiological experiences, like increased heart rate from rushing through the mall. Though the grave consequences that they fear never occur, patients are not easily convinced that they won't happen the next time. They continue to believe that they escaped catastrophe by fleeing and the next attack may finally bring it on.

Cognitive therapy is a form of psychotherapy that is used to help patients replace inaccurate, distorted, thinking with more accurate self-statements. In conducting cognitive therapy, the therapist works together with the patient to build a compelling argument that the patient's fears are irrational. Several sources of information are used to help patients think more accurately when their anxiety symptoms increase. One source of information is the patient's personal history of panic attacks. How many panic attacks, both large and small, have they experienced? How many predictions of catastrophe? How many actual catastrophes? A second source of information used to counter distorted thinking is the experiences of other panic disordered patients. How many patients with panic disorder seen at the anxiety clinic? (about 3,000 at last count), How many panic attacks in total? (many thousands) How many predicted catastrophes? (many thousands) How many actual catastrophes? (the answer is none, of course).

Another cognitive procedure is usually referred to as behavioral experiments. This technique is used to counter the commonly held belief that a particular patient's panic attacks are dangerous, different from the panic attacks that other patients experience. Most patients with panic disorder use several strategies in order to control their panic and prevent a catastrophe, including, fleeing the situation, taking a drink of water, eating something, or distracting themselves. During behavioral experiments, patients are asked to allow panic attacks to run their course, without interruption, in order to learn first hand that their panic attacks, like other patient's panic attacks, only seem to signal an impending calamity. So we say, "let the panic attack happen and let yourself experience it, using the cognitive techniques you are taught to help you through it; and it will become less frightening." This is very different from simple reassurance that nothing serious is wrong. Reassurance alone is not helpful and tends to undermine self-esteem. Patients need to know that we understand that they can't just talk themselves out of their fear. But we need to convince them that they can at least put up an argument. If practiced regularly, the cognitive techniques described above are often helpful in reducing the frequency and intensity of attacks.

Goal 2: Reduce fear of the physical symptoms associated with panic or anxiety (reduce anxiety sensitivity)

Technique: Exposure and desensitization to somatic cues

Approach: Systematic, paced, and repetitive exposure to the physical symptoms that they find most frightening. For those focused on cardiac symptoms and fear they are having a heart attack, we use exposure to the sensation of a pounding heart induced by exercise. For those focused on dizziness and fear of fainting, we use exposure to dizziness induced by spinning. For those frightened of lightheadedness or tingling, we use exposure to neurological symptoms induced by hyperventilation. The exposure process (called interoceptive exposure) is taught in session, and then practiced daily by patients in homework assignments.

Goal 3: Reduce fear and avoidance of agoraphobic situations

Technique: Exposure and desensitization

Approach: Systematic, paced, and repetitive exposure to the situations that are frightening and avoided. The exposure process is taught in session and then practiced daily by patients in homework assignments. The principle is very simple. If you are afraid of driving, the solution is to drive. If you are afraid of going to the mall, the solution is to go to the mall. The key is to accumulate sufficient exposure, properly paced, to allow the patient to sit through anxious distress long enough to allow it to extinguish, without removing themselves from exposure to the anxiogenic cues.

Variations on Panic CBT for Other Anxiety Disorders:

Obsessive Compulsive Disorder (OCD)

Exposure and Response Prevention

Cognitive restructuring is less helpful in patients with OCD. The critical ingredient for successful CBT with OCD patients is direct exposure to the situations that trigger the patient's obsessions or compulsive rituals. This technique is referred to as exposure therapy. Simple exposure to fearful stimuli, however, is not enough for these patients. When patients expose themselves to anxiety provoking stimuli they must block any rituals used to prevent the harm that they anticipate as a consequence of the exposure. This technique is referred to as response prevention. Exposure and response prevention are used together in the behavioral treatment of OCD. For example, a patient with contamination fear and washing compulsions must practice repeated and extended exposure to his or her feared sources of contamination (e.g., touching door knobs, the floor, toilet seats) and resist all urges to wash or engage in any other "decontaminating" or anxiety reducing ritual in response to the exposure. At least 20 hours of actual exposure and response prevention are usually necessary for clinically meaningful desensitization to occur.

Obsessions are intrusive, disturbing thoughts that generate anxiety, disrupt functioning, but cannot be controlled by the patient. They often have violent, sexual, or blasphemous content. Patients with pure obsessions (no compulsive behaviors) are more difficult to treat behaviorally, but techniques using prolonged exposure to taped recordings of their obsessions, in their own voices, can be effective in some cases.

Social Phobia

Cognitive restructuring: The cognitive work focuses on distorted expectations of negative social outcomes and hypercritical self-evaluations in social situations. Patients are taught to identify their negative thoughts (e.g. "It would be awful to make a mistake and say the wrong thing;" "I am a loser"), to find ways to concretely test and disconfirm them, with the goal of replacing these thoughts with more accurate self-statements.

Exposure work: The basic principle of graded exposure to increasingly challenging situations, with sufficient duration to allow desensitization to occur, is the same as in all exposure based treatments. The keys to treatment are development of appropriately graded exposure exercises to the patient's personally relevant social cues and compliance with exposure exercises of adequate frequency and duration. Group treatment is particularly useful as it provides a ready context for developing and practicing exposure exercises. Observing and correcting a fellow patient's obviously distorted self-assessments of performance is a powerful way to convince a patient that his or her self-assessments may also be distorted.

Specific Phobia

Exposure work: This provides the simplest application of the basic principle. Graded exposure inevitably leads to desensitization. The key is developing an appropriate set of graded exposure exercises and obtaining the patients compliance with them. The treatment is very straight forward with easily manipulated phobic objects (e.g., dogs, snakes, spiders, heights, driving) and somewhat more challenging, but still quite feasible, with less easily controlled phobic cues (e.g., airplanes, storms).

Generalized Anxiety Disorder (GAD)

Techniques for the treatment of GAD are less well developed and less well studied. Because GAD is primarily a "worry" disease, its manifestations are largely cognitive and emotional rather than behavioral. Avoidance is not usually a dominant aspect of the presentation. The worries themselves tend to be very diffuse. This makes it difficult to design specific interventions based on the exposure principle. The work is therefore primarily cognitive. We perceive it as more difficult and its effectiveness is less well established. We tend therefore to rely more exclusively on medication for this disorder.

Post Traumatic Stress Disorder (PTSD)

Cognitive work: Focuses on helping patients understand their physiological reactivity as an understandable response to traumatic exposure and not evidence they are "going crazy." Also helps them reconstruct their shattered worlds, so they can engage in more realistic assessment of risks, their own competence, and the trustworthiness of other people.

Exposure work: Patients are often highly sensitized to specific cues linked to the traumatic experience. These require systematic exposure and desensitization. All avoidance needs to be addressed, whether it is of places, people, situations, or memories. Because of patients' sensitivities and reactivity, this work requires therapists who are particularly skilled, experienced, and interested in this type of work.